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Tuesday, July 4, 2017

Michaelis and Menten's equation is an hyperbola

It is mentioned in the lecture that Michaelis and Menten's equation is an hyperbola, but there isn't a proof, here it is:

Let x=[s] and y=v0 as we see in the graph. Let m=vmax and k=km to simplify notation. We have

y=mxk+x(k+x)y=mxky+xy=mx

The xy term is annoying, so we let x=X+Y and y=XY, this is a linear transformation that simply rotate and scales, so we have

k(XY)+(X+Y)(XY)=m(X+Y)kXkY+X2Y2=mX+mY

Now we can see why it is a hyperbola - simply complete the square will lead us to the standard hyperbola.

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