In a healthy individual, fat is stored in a thin layer under the skin and around internal organs, that serves the purpose of insulation and padding.
Adipocytes contain one very large lipid droplet.
The excess fat is stored by increasing both adipocytes size and cell numbers.
Cachexia and Lipodystrophy are lack of lipid droplets, they cannot be correct because ectopic deposition is the abnormally large amount of lipid droplets.
The correct answer are the remaining two:
Metabolic syndrome resulting from caloric imbalance, and
Neutral lipid storage disease, myopathy subtype.
They are both diseases from a unique genetic mutation and Ichthyosis results from an unknown ATGL-independent function of ABHD5 that affects the skin’s lipid matrix.
It originates from dietary intake of fat, carbohydrates and proteins.
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