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Sunday, July 2, 2017

Introduction to Biochemistry - Quiz 2.3.4.1


A zymogen is an inactive precursor of an enzyme that can be hydrolyzed into an active enzyme. It is also called proenzyme.


My analysis is the following, both the timing and the location is important, while I don't know what the third choice is, it has to be correct. Therefore the answer is "All of the above". I googled a bit - proteome is simply the set of all proteins.


A signaling sequence is a sequence for secretion of a protein found in a leader peptide at the N-terminal of a protein. It is used to lead the protein to its destination organelle after it is synthesized.


The inactive form of chymotrypsin is called chymotrypsinogen. It is stored in the pancreas.


The ile faces towards the exterior of the protein in chymotrypsinogen. When the chymotrypsinogen is cleaved at ile by trypsin the ile turns inwards and forms an ionic bond with Asp194 inducing a conformational rearrangement that activates the enzyme.


Proinsulin is the inactive precursor of insulin.


First the signal peptide is cleaved, then Proinsulin formed. Aften that, the c-peptide is cleaved and both the insulin and c-peptide are excreted.

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