Introduction to Biochemistry - Quiz 1.1.2

To put it simply, two different 3D structures are called conformations of each other if a molecule can transform from one to another without having to break a bond. Otherwise it is a configuration change.

Therefore, the first answer is:

"The (potentially flexible) spatial arrangement of atom around fixed bonds in a molecule"

And the second answer is:

"The fixed arrangement of atoms dictated by bonds of a molecule"

The molecule is chiral - a molecule is chiral if there exists a carbon atom such that it is bonded to 4 different groups. Such an atom could be bonded differently (e.g. swapping the H and F in the question) to form another molecule, that molecule is in a different configuration but it is impossible to superimpose the two molecules.

It is also chiral, and it has a lot of chiral centers

This is a little tricky - the answer is no. The drawings are exactly the same thing.